Midwest People – Find your flow

Main Menu

  • Midwest People
  • Family
  • Fashion
  • Health
  • Home
  • Shopping
  • Society
  • Travel

logo

  • Midwest People
  • Family
  • Fashion
  • Health
  • Home
  • Shopping
  • Society
  • Travel
Health
Home›Health›Scientists Anticipate That Automation in Workflow Will Improve CAR-T Therapy

Scientists Anticipate That Automation in Workflow Will Improve CAR-T Therapy

By Milt Hunt
November 24, 2021
765
0
Share:

Researchers focused on treating patients with cancer are looking at new automated systems to improve their ability to develop CAR-T therapy solutions. In the world of cancer immunotherapy, scientists deploy chimeric antigen receptors or CAR-T cells, which they use to identify cancer cells in the body and then destroy them.

Of particular interest to researchers is the promise of CAR-T to prevent cancer cells from evading the body’s immune system.

About CAR-T Therapy

The incidence of hematological malignancies (or blood cancers)  is prompting researchers to step up their experiments in cancer immunotherapy. Automating as much of this research as possible speeds up development and helps with accuracy and reproducing results faithfully in the lab.

Doctors begin by extracting whole blood cells from patients. If they take the blood from the patient receiving therapy, it’s an autologous procedure. If they take blood from another donor, it’s referred to as allogenic.

Then the scientists use a process called leukapheresis to fraction the blood, collecting the needed T cells. After extraction, they expand and transduce the T cells using material encoding CARs before introducing them (or reintroducing them as the case may be) to the patient.

With many steps along the way in this complex process, there is plenty of room for error, especially when the techniques are mostly done manually. That’s why automation of the essential work here is so valuable to scientists. Doing so saves time and cuts down on human error in research.

Keep in mind that the industry is still in development, with much more effort needed in areas such as research, manufacturing equipment, determining production timeframes, and dealing with the high costs of manufacturing such devices (especially on a smaller scale during the initial phases of development.). That’s to be expected since scientists cannot enjoy production prices at a scale until they have tested and improved prototypes.

Researchers from the Centre for Commercialization of Regenerative Medicine (Ontario, Canada) have been busy evaluating various CAR-T cell unit systems along with reagents and equipment for possible use in processing their experiments, per RegMedNet.

Recent work has had the researchers processing thawed apheresis units and isolating T-cells from samples. Then, they seeded isolated T cells in flasks that are activated with specific cell activators supplied by STEMCELL Technologies. The shake flasks reduced the time of hand manipulation of samples by half, making it more efficient than earlier approaches. After the T-cells are transduced in the equipment, they are expanded in a cell expansion system over an 8-day process.

RegMedNet explains that this process is much more efficient because of automation, paving the way toward faster development and evaluation of new CAR-T therapies.

Equipment in Cancer Immunotherapy Research Experiments

To take advantage of CAR-T therapy mechanisms, researchers need equipment with software that’s easy to operate in a lab setting. As noted by The Scientist, engineers and scientists have joined forces to develop the Gibco Cell Therapy System’s Rotea Counterflow Centrifugation System.

It’s compact and works with single-use kits for CAR-T cell production and cell therapy research. The system automates cell processing so it’s done much faster than when people do it manually. What’s more, it can work with volumes as small as 5 ml. With a tiny amount of material, scientists can collect samples with high concentrations reaching 300 million/ml.

The Future of Cancer Therapy Research and Development

As scientists continue with their experiments in cancer immunotherapy, systems that allow for automated work using CAR-T cells will surely find more use in laboratory settings. Automating CAR-T experiments means they can conduct more tests in less time, which is key toward developing promising new therapies.

Previous Article

San Miguel Mexico: A Dream Come True

Next Article

Mesenchymal Stem Cells for the Treatment of ...

0
Shares
  • 0
  • +
  • 0
  • 0
  • 0
  • 0

Related articles More from author

  • Health

    The Very Best Dental Plans – Finding the right Plan

    November 16, 2020
    By Milt Hunt
  • Health

    Herbal Health – Important Advantages of Herbal Health

    November 6, 2017
    By Milt Hunt
  • Health

    Consuming Alkaline Water for much better Health

    January 16, 2018
    By Milt Hunt
  • Health

    Frequently asked questions on CBD tincture

    July 10, 2021
    By Milt Hunt
  • Health

    The Pros & Cons of Donating Plasma

    January 1, 2022
    By Milt Hunt
  • Health

    Everything You Need to Know to Buy Legal Weed in California

    April 27, 2021
    By Milt Hunt

  • Home

    Just A Little Info on Contemporary Interior Planning

  • Home

    Professional and Dedicated Senior Assisted Living Service

  • Family

    Safe Essential oils for babies

Health

The Ultimate Guide to Treating Urologic Infections

Urologic infections are a common and often painful medical problem that can impact a person’s quality of life. From urinary tract infections (UTI’s) to bladder infections and kidney infections, these ...
  • The Perfect Grandparents’ Bedroom Design Ideas

    By Milt Hunt
    March 1, 2023
  • The Most Trending Floor Coating Materials In 2023

    By Milt Hunt
    February 1, 2023
  • Everything You Need To Know About Sclerotherapy

    By Milt Hunt
    February 1, 2023
  • An Overview Of Venture Debt

    By Milt Hunt
    February 1, 2023

Recent Posts

  • The Ultimate Guide to Treating Urologic Infections March 8, 2023
  • The Perfect Grandparents’ Bedroom Design Ideas March 1, 2023
  • The Most Trending Floor Coating Materials In 2023 February 1, 2023
  • Everything You Need To Know About Sclerotherapy February 1, 2023
  • An Overview Of Venture Debt February 1, 2023
  • Role of social workers in helping families February 1, 2023
  • How a Corporate Travel Consultant Can Save Your Company Time and Money January 2, 2023

2023

  • – March (2)
    • The Ultimate Guide to Treating Urologic Infections
    • The Perfect Grandparents’ Bedroom Design Ideas
  • + February (4)
  • + January (1)

2022

  • + December (2)
  • + November (6)
  • + October (4)
  • + September (1)
  • + July (1)
  • + June (2)
  • + May (1)
  • + April (1)
  • + March (1)
  • + January (2)

2021

  • + November (2)
  • + October (3)
  • + September (5)
  • + August (3)
  • + July (7)
  • + June (2)
  • + May (1)
  • + April (2)
  • + January (1)

2020

  • + December (2)
  • + November (4)
  • + August (1)
  • + May (1)
  • + April (1)
  • + February (1)

2019

  • + November (1)
  • + September (1)
  • + July (2)
  • + May (1)
  • + March (1)
  • + February (3)
  • + January (3)

2018

  • + December (2)
  • + November (6)
  • + October (2)
  • + September (2)
  • + August (4)
  • + July (4)
  • + June (2)
  • + May (4)
  • + April (2)
  • + March (1)
  • + February (4)
  • + January (10)

2017

  • + December (11)
  • + November (4)
  • + October (3)
  • + September (3)
  • + August (4)
  • + July (4)
  • + June (3)
  • + May (3)
  • + April (4)
  • + March (3)
  • + February (2)
  • + January (3)
  • Your Inquiry
Copyright © 2020 Midwest People. All Rights Reserved.